Pharmacogenetics studies the genetic factors that determine the different responses to medicines, examining both the beneficial and desired effects and the adverse and unwanted ones.
Individual responses to pharmacological treatment are very different from individual to individual and this variability constitutes one of the most relevant problems in clinical practice.
Recent advances in analytical methodologies have allowed the discovery of several allelic variants in genes involved in drug metabolism, pharmacokinetics or pharmacodynamics. These are the alterations that may be related to chemosensitivity or tolerance towards drugs.
The ultimate goal of pharmacogenetics is to examine the individual genetic profile of the patient and personalize the choice and dosage of drugs, to increase the probability of success of a therapy and reduce the risk of dangerous side effects or ineffective therapy.
Genechron offers specific tests for the evaluation of chemotherapy therapies by analyzing the genes specifically involved in treatment with monoclonal antibodies: BRAF, EGFR, K-RAS, N-RAS.