Nutrigenetics

Genechron proposes the analysis of the following polymorphisms:

GENETIC TEST FOR LACTOSE INTOLERANCE: LCT (C-I39I0T, A-220I8G).

The test is performed starting from a simple buccal swab or a blood sampling and allows you to have a definitive response regarding individual lactose intolerance. The test is aimed at all those people who show a symptomatology characterized by abdominal swelling, diarrhea, presence of intestinal gas, abdominal pain and cramps, nausea, flatulence.

GENETIC TEST FOR PREDISPOSITION TO CELIAC DISEASE: HLA-DQ2 e DQ8.

The test is performed through blood sampling and is aimed at those who suffer from chronic fatigue, iron anemia, weight loss without apparent cause, to those who have familiar with celiac disease, to those who have had an unclear diagnosis on celiac disease. The genetic test included in the sensitivity panel identifies predisposition aplotypes (Hladq2 and DQ8) revealing a possible genetic predisposition to celiac disease.

GENETIC TEST FOR HISTAMINE INTOLERANCE: AOC1 A594 A/T (rs2268999), AOC1 4586G/T (rs2052129), AOC1 4106C/G (rs1049793), AOC1 995C/T (rs1049742); AOC1 47C/T (rs10156191), HDC 1932A/C (rs2073440), HNMT 939A/G (rs1050891), HNMT 314C/T (rs11558538).

Histamine is a substance produced by the body during digestion. Some subjects following the intake of foods that lead to a high production of histamine (example, chocolate, citrus fruits, dried fruit) show a reaction similar to an allergy. To know if you are sensitive to histamine allows you to monitor the consumption of these substances and manage its symptoms.

GENETIC TEST FOR CAFFEINE SENSITIVITY: CYP1A2(*1F*1*A).

The test is dedicated to all coffee consumers, tea and all foods containing caffeine. The CYP1A2 gene is responsible for the metabolism of the substance and in some subjects it can be present with a variant that causes slow absorption. In these subjects, attention should be paid to the amount of caffeine consumed as the risk of heart attack has increased.

GENETIC TEST FOR NICKEL SENSITIVITY: FLG e TNFa.

Nichel is a metal contained in numerous food and non -food products. People suffering from hypersensitivity to nickel show problems ranging from dermatitis to headaches. The test performed with salivary buffer allows the identification of the two genes involved in sensitivity: FLG and TNFA.

GENETIC TEST FOR ALCOHOL SENSITIVITY: ALDH2 (E504K), ADH2 (H48R), ADH1C (I350V).

Alcohol sensitivity arises from the presence of genetic defects that modify the production of enzymes involved in alcohol metabolism and which involve a inability to correctly metabolize the quantities of alcohol taken.

INTOLERANCE COMPLETE PANEL

The test allows you to establish dietary recommendations capable of minimizing the risk of developing specific diseases due to incorrect intake of food and identifying any food intolerances in order to quickly restore a metabolic balance. The test allows to evaluate: intolerance or lactose sensitivity, genetic predisposition to celiac disease, sensitivity to caffeine, sensitivity to histamine, sensitivity to nickel and sensitivity to alcohol. The information on individual tests is described in the previous paragraphs.

METABOLIC HEALTH PANEL

The test allows you to evaluate: the predisposition to the weight gain and therefore a risk to overweight and obesity; the predisposition to type 2 diabetes; the predisposition to the metabolic syndrome; The predisposition to an increase in cardiovascular risk linked to hyperlipidemias, high levels of triglycerides and/or increase in cholesterol. The metabolic health panel is aimed at those who want to deepen knowledge on their ability to metabolize carbohydrates and lipids and evaluate their genetic predisposition on conditions that favor alterations of the metabolism and the increase in weight. This test is aimed at adult subjects, since studies have not been carried out on individuals in pediatric age.

SPORT PERFORMANCE PANEL

A DNA test aimed at identifying a series of polymorphisms that may involve changes in the functionality of some biological processes (for example, increasing the predisposition to one sporting discipline compared to another). The goal is to increase the level of sports performance in relation to the adoption of the most suitable food style through the analysis of polymorphisms in a series of genes involved in important metabolic processes such as the control of intolerances and the predisposition to power efforts or resistance.

BONES METABOLISM AND OSTEOPOROSIS PANEL

The genetic test analyzes a group of genes involved in the regulation of characters related to the development of osteoporosis, such as mass and bone micro -architecture. Osteoporosis is the most frequent metabolic disease of the skeleton, characterized by a reduction in bone mass and an alteration of micro -architecture, with consequent increase in fragility and probability of incurring a fracture. The onset of osteoporosis is the result of complex interactions between genetic predisposition and environmental risk factors.

HOMOCYSTEINE METABOLISM PANEL

High levels of homocysteine in the blood represent a cardiovascular risk factor that can aggravate the effects of the other risk factors on the wall of the blood vessels. The cigarette smoke and the dietary intake of folato and vitamin B12 are decisive for the concentrations in the blood of omocysteine. High plasma homocysteine values are also related to repeated abortions and increased risk for thrombotic events. The genetic test consists in the analysis of the polymorphisms mentioned in the CBS genes, MTHFR, MTR, MTRR, TCN2 and provides useful information to determine a personalized diet that allows you to decrease the plasma levels of homocysteine and to reduce cardiovascular risk.

HEALTH COMPLETE PANEL

The test analyzes variations against coding genes for: antioxidant enzymes to identify a genetic predisposition to an increased risk of susceptibility to oxidative stress; the enzyme involved in the metabolism of homocysteine (MTHFR) to detect alterations of functionality that can lead to a risk due to the accumulation of homocysteine in the blood; Some cytokines, in particular TNFα, Il-6 and Il-10, to identify a genetic predisposition to a greater risk of developing chronic inflammation. The test includes the analysis of genetic predisposition to osteoarthritis and osteoporosis. The Complete Health Panel is suitable for those who have a widespread symptomatology or who have a familiarity for different classes of pathologies or even those who need and the desire to undertake a path of prevention and protection of the state of well-being.

SPORT AND WELLNESS COMPLETE PANEL

The test allows you to evaluate: genetic predisposition to the type of sport (power, resistance, speed); the susceptibility to injuries (lesions of tendon ligaments and tendency to tendinopathies and osteopathies); The predisposition to overcome situations of strong stress in a competitive environment. The test also allows to evaluate: the predisposition to the weight gain and therefore a risk to overweight and obesity; the predisposition to type 2 diabetes; the predisposition to the metabolic syndrome; The predisposition to an increase in cardiovascular risk linked to hyperlipidemias, high levels of triglycerides and/or increase in cholesterol. The complete sport and wellness panel is partially based on the analysis of genetic variants analyzed and published following scientific studies of sports nutrigenetics, partly on the analysis of genes involved in the predisposition to type 2 diabetes mellitus, hyperlipidemia, obesity, cardiovascular risk and metabolic syndrome. The analysis of these genes allows to identify variants that can determine the predisposition towards a potential risk factor or a potential protective factor. The panel is suitable for those who practice sports at amateur or competitive level, in order to obtain useful information to improve performance and prevent accidents and to those who want to deepen knowledge on their ability to metabolize carbohydrates and lipids or on their genetic predisposition at conditions that they favor weight gain.